Steve K. Juhn, MD

Contact Information Phone: 612-626-9879 Fax: 612-626-9871 Email: juhnx001@umn.edu Address: #209 Lions Research Bldg. 2001 6th Street S.E. Minneapolis, MN 55455

Professor

Research

After completing the post-doctoral fellowship at the University of Duesseldorf, Dr. Juhn joined the Department of Otolaryngology (Head: Dr. Michael Paparella) and established the Auditory Biochemistry Labortory. The followings are major projects of the Laboratory:

1. Pioneered biochemical aspect of middle ear inflammation dealing with the nature of middle ear effusion (both human and animals in experimental otitis media) and the effects of inflammatory mediators on the inner ear tissues and function. 

2. Established the biochemical nature of inner ear fluid and factors involved in the alteration of the fluid composition in experimental otitis media (stress hormones and inflammatory mediators).

3. Established the concept of a blood-labyrinth barrier and its role in the inner ear function.

4. Biochemical pathology of age-related hearing loss and management.

5. Application of stem cells on the restoration of inner ear lateral wall and auditory function.

6. New treatment strategies for otitis media.

7. Identification of candidate genes in familial Meniere’s Disease.

Education & Training

Medical School
Kyung-pook University

Fellowships
International Atomic Energy Fellowship, University of Bologna, Italy
NIH Fogarty Senior Fellowship, Karolinska Institute, Sweden

Graduate School
Seoul National University, University of Duesseldorf, Germany

Selected Publications

Ikeda K, Sakagami M, Morizono T, Juhn SK. Permeability of the round window membrane to middle-sized molecules in purulent otitis media.  Arch Otolaryngol Head Neck Surg 116:57-60, 1990.

Jung TTK, Park YM, Schlund D, Weeks D, Miller S, Wong O, Juhn SK. Effect of prostaglandin, leukotriene, and arachidonic acid on experimental otitis media with effusion in chinchillas.  Ann Otol Rhinol Laryngol 99:28-32, 1990.

Amesara R, Kim Y, Sano S, Harada T, Juhn SK.  Primary culture of middle ear epithelial cells from chinchillas. Eur Arch Otorhinolaryngol 249:164-167, 1992.

Lundman LA, Santi P, Morizono T, Harada T, Juhn SK, Bagger-Sjöbäck D. Inner ear damage and passage through the round window membrane of Pseudomonas aeruginosa exotoxin A in a chinchilla model.  Ann Otol Rhinol Laryngol 101:437-444, 1992.

Antonelli PJ, Juhn SK, Goycoolea MV, Giebink GS. Pseudomonas otitis media after eustachian tube obstruction.  Otolaryngol Head Neck Surg 107:511-515, 1992.

Harada T, Kim Y, Juhn SK, Sakakura Y. Biochemical characterization of mucous glycoproteins secreted by in vitro chinchilla middle ear epithelial cells.  Eur J Otolaryngol 250: 182-185, 1993

Juhn SK, Garvis WJ, Lees CJ, Le CT, Kim CS: Determining otitis media severity from middle ear fluid analysis.  Ann Otol Rhinol Laryngol 103(Suppl 163):43-45, 1994.

Kim SJ, Juhn SK. Two types of K+ currents in marginal cells from rat stria vascularis. Hear Res 112:196-198, 1997.

Lin J, Kim Y, Juhn SK.  Increase of mucous glycoprotein secretion by tumor necrosis factor alpha via a protein kinase C-dependent mechanism in cultured chinchilla middle ear epithelial cell.  Ann Otol Rhinol Laryngol 107:213-219, 1998

Juhn SK, Li W, Kim JY, Javel E, Levine S, Odland RM. Effect of stress-related hormones on inner ear fluid homeostasis and function.  Am J Otology 20:800-806, 1999.

Juhn SK, Hunter BA, Odland RM. Blood-labyrinth barrier and fluid dynamics of the inner ear. Int Tinnitus J 7:72-83, 2001.

Hunter BA, Lee S, Odland RM, Juhn SK. Estimation of perilymph concentration of agents applied to the round window membrane by microdialysis. Acta Otolaryngol. 123:453-458, 2003.

Preciado DA, Caicedo E, JhangjeeR, Silver R, Juhn SK, Choo DI, Ondrey FG. Pseudomonas aeruginosa lipopolysaccharide induction of keratinocyte proliferation, NF-kappa B, and cyclin D1 is inhibited by indomethacin. J Immunol 174:2964-2974, 2005.

King TA, Ghazaleh RA, Juhn SK, Adams GL, Ondrey FG. Induction of heat shock protein 70 inhibits NF-kappa-B in squamous cell carcinoma. Otolaryngol Head Neck Surg 133:70-79, 2005.

Juhn SK, Tsuprun V, Oh S, Flanagan C, Javel E. Biochemical pathology of inner ear caused by middle ear infection. Proceedings of 6th Symposium on Recent Advances in Otitis Media Research, 2005 .

Juhn SK, Lee JE, Jung MK, Lee S, Kim BH.  Effects of Aging on Auditory Function. Kor. J Gerontology 15: 1-7, 2005.

Schachern PA, Tsuprun V, Cureoglu S, Ferrieri P, Briles DE, Paparella MM, Juhn S. The round window membrane in otitis media. Effect of pneumococcal proteins. Otolaryngol Head Neck Surg 2008 (in press).

Tsuprun V, Cureoglu S, Schachern PA, Ferrieri P, Briles DE, Paparalla MM, Juhn SK, Role of pneumococcal proteins in the sensorineural hearing loss due to otitis media. Otolaryngol Head Neck Surg 2008 (submitted).

Juhn SK, Jung MK, Hoffman MD, Drew BR, Preciado A. Sausen NJ, Jung TTK, Kim BH, Park SY, Lin J, Ondrey FG, Huang T.  The role of inflammatory mediators in the pathogenesis of otitis media.  International J of  ORL & HNS-Auris Nasus Larynx . 2008 (submitted).

Juhn SK, Tsuprun V, Kim B, Jung M, Lee J, Cureoglu S, Lee S, Mains DR, Heman-Ackah SE.  Pathological factors in age-related hearing loss.  J Aging Dev. 2008 (submitted).

Honors and Awards

International Atomic Energy Agency Fellowship
Society of the Sigma Xi
Honor Award, American Academy of Otolaryngology, 1980
Collegium of Otolaryngology, 1982
Fogarty Senior International Fellowship (NIH), 1984
Guest of Honor, International Tinnitus Society,  2001